Iin Fadhilah Utami
Hasanuddin University, Indonesia
Title: Correlation between Hyperuricemia, Hypertension and Coronary Artery Disease (CAD): A crosssectional study
Biography
Biography: Iin Fadhilah Utami
Abstract
Introduction: Serum uric acid is an end product from metabolism in purine, an increased risk of hypertension, cardiovascular disease, and chronic kidney disease have been shown to be associated with serum uric acid in previous epidemiological studies. In contrast, a number of studies have suggested that uric acid is not independent of other established risk factors, especially hypertension, for the development of cardiovascular disease. Whether serum uric acid contributes to the disease progress is still controversial. This study aimed to analyze and compare the correlation between serum uric acid level, hypertension, and severity of coronary artery disease.
Methods: This is an observational study with cross sectional approach of 131 patients of coronary artery disease in Cardiac Center of Wahidin Sudirohusodo Hospital. Data analyzed using SPSS 20.0
Results: A total of 131 coronary artery disease patients examined (mean age 57 ± 7.7 years), The total 56 of hypertensive patients has among them 23 (41,1%) hyperuricemia statuses and 33 (58,9%) without hyperuricemia with its p value >0,05. From 36 patients having diabetic status, 15 (42,9%) of them had hyperuricemia and 20 (57,1%) with normal serum uric acid levels with p value >0,05. And for the severity of coronary artery disease, our results showed that the mean value of gensini score in normal serum uric acid level was 12,7 as almost the same with 12,1 in hyperuricemia patients with p value >0,05. Although the hyperuricemia comprised the most in severe coronary artery disease (44,8%) but with p value >0,05 showing that there was no significance found. However, our results found that the severity of coronary artery disease was associated with body mass index (p value: 0,004) with 91 (69,5%) of samples having abnormal (overweight/obese) BMI. Also, severe coronary artery disease was mostly found in 39 (73,6%) patients who had abnormal BMI (overweight/obese).
Conclusion: In conclusion, the mechanisms of hyperuricemia associated with atherosclerotic vascular disease or whether it is a valuable marker for cardiovascular disease remain to be clarified. Further studies and large samples research that focused on correlation between hyperuricemia, hypertension and coronary artery disease are expected.